Symbol
Name
ID

Il2
interleukin 2
MGI:96548

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Decreased circulating IgG level

Decreased circulating IgG2 level

Defective B cell differentiation

Abnormal B cell count

Decreased proportion of CD4-positive helper T cells

T lymphocytopenia

Lymphopenia

Leukopenia

Hemophagocytosis

Leukemia

Acute lymphoblastic leukemia

Sinusitis

Stomatitis

Allergic rhinitis

Conjunctivitis

Pericarditis

Lymphadenopathy

Hypoplasia of the thymus

Hepatosplenomegaly

Gastrointestinal inflammation

Recurrent gastroenteritis

Peritoneal abscess

Acute hepatitis

Chronic hepatitis

Subacute progressive viral hepatitis

Iridocyclitis

Inflammatory abnormality of the eye

Epididymitis

Lupus nephritis

Nephritis

Abnormality of the immune system

Fasciitis

Inflammatory abnormality of the skin

Eczematoid dermatitis

Atopic dermatitis

Erythema nodosum

Recurrent skin infections

Discoid lupus rash

Maculopapular exanthema

Malar rash

Myositis

Pneumonia

Serositis

Decreased circulating complement C3 concentration

Decreased circulating complement C4 concentration

Autoimmunity

Anti-citrullinated protein antibody positivity

Antineutrophil antibody positivity

Perinuclear antineutrophil antibody positivity

Antinuclear antibody positivity

Anti-dsDNA antibody positivity

Anti-La/SS-B antibody positivity

Anti-Sm antibody positivity

Anti-U1 ribonucleoprotein antibody positivity

Antiphospholipid antibody positivity

Platelet antibody positive

Rheumatoid factor positive

Systemic lupus erythematosus

Asthma

Recurrent infections

Recurrent lower respiratory tract infections

Recurrent bronchitis

Disease(s) Associated with IL2

alopecia areata

asthma

ataxia telangiectasia

atopic dermatitis

autoimmune thrombocytopenic purpura

Behcet's disease

graft-versus-host disease

hepatocellular carcinoma

pancreatic cancer

rheumatoid arthritis

systemic lupus erythematosus

type 1 diabetes mellitus

Mouse Phenotypes

immune system phenotype

heart inflammation

increased B cell proliferation

abnormal T cell proliferation

decreased T cell proliferation

increased T cell proliferation

decreased splenocyte proliferation

large intestinal inflammation

colitis

salivary gland inflammation

abnormal thymocyte activation

lacrimal gland inflammation

pancreas inflammation

enlarged spleen

spleen hyperplasia

abnormal class switch recombination

increased pro-B cell number

abnormal T-helper 1 cell differentiation

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

increased susceptibility to autoimmune hemolytic anemia

abnormal lymphocyte cell number

increased germinal center B cell number

increased plasma cell number

increased pre-B cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased T-helper 17 cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased regulatory T cell number

increased regulatory T cell number

increased T cell number

increased activated T cell number

increased single-positive T cell number

abnormal lymphocyte morphology

abnormal CD8 positive, alpha-beta intraepithelial T cell morphology

abnormal gamma-delta intraepithelial T cell morphology

abnormal spleen morphology

increased spleen red pulp amount

increased splenocyte number

abnormal lymphocyte physiology

increased IgA level

increased IgE level

increased IgG1 level

increased IgG2a level

increased IgG2b level

increased IgG level

impaired natural killer cell mediated cytotoxicity

abnormal CD4-positive, alpha-beta T cell physiology

abnormal cytotoxic T cell physiology

decreased cytotoxic T cell cytolysis

abnormal T cell activation

abnormal regulatory T cell physiology

abnormal circulating cytokine level

decreased circulating interferon-gamma level

decreased circulating interleukin-13 level

decreased circulating interleukin-17 level

increased circulating interleukin-17 level

decreased circulating interleukin-4 level

enlarged mesenteric lymph nodes

enlarged lymph nodes

lymph node hyperplasia

abnormal level of surface class II molecules

abnormal susceptibility to autoimmune disorder

increased susceptibility to autoimmune disorder

increased susceptibility to autoimmune diabetes

increased inflammatory response

liver inflammation

lung inflammation

abnormal susceptibility to Riboviria infection

abnormal response to transplant

increased length of allograft survival

Availability

Mouse Genotype

Il2^m1/Il2^m1

Il2^tm1.1Flv/Il2^tm1.1Flv

Il2^tm1Hor/Il2^tm1Hor

Il2^tm1Hor/Il2⁺

Il2^tm1.1Kasm/Il2^tm1.1Kasm
Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23